This cluster focuses on the risk and protective factors influencing mental health and well-being from early years through to adolescence and youth. Research on issues of stress, depression, alcohol consumption, self esteem and social support are explored. Suicide is considered both in terms of suicidal behavior and associated risk factors and mediating psychological constructs, as well as the use of machine learning to predict substance behavior in adolescents. This cluster also focuses on the factors that contribute to stigma associated with mental health problems, including ADHD and depression.